Flagship guide · Free download

The House of AI Trust™

A five-layer model for trustworthy AI in regulated drug development workflows.

The guide sets out the full architecture — and the control layer that converts governance from a set of principles into evidence an inspector can actually examine.

Inside · 01

25-point readiness checklist

An organizational self-assessment across all five layers, scored so you can see which floor is missing before you build on top of it.

Inside · 02

Regulatory timeline

What FDA, EMA, and the GAMP 5 / GAMP AI Guide lineage have asked sponsors to demonstrate, and when each expectation lands.

Inside · 03

The control layer, in full

Layer 3 in operational detail, including the Britt Probabilistic Validation Lifecycle — the seven-step model for systems where reproducibility is bounded.

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The House of AI Trust — Interactive
The House of AI Trust™

Five layers. Four threads. One defensible system.

Each layer rests on the one beneath it. Four threads run vertically through all of them. Hover a layer — or a thread — to see what it covers.

Four threads run through every layer
L5
Business ROI
Makes AI investable
L4
Domain + Process Context
Makes AI useful
L3
The Control Layer
Makes AI defensible — where validation happens
L2
AI Governance
Makes AI manageable
L1
Trust Infrastructure
Makes AI possible — the foundation